Functional Connectivity Substrates for tDCS Response in Minimally Conscious State Patients

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Functional Connectivity Substrates for tDCS Response in Minimally Conscious State Patients

Transcranial direct current stimulation (tDCS) is a non-invasive technique recently employed in disorders of consciousness, and determining a transitory recovery of signs of consciousness in almost half of minimally conscious state (MCS) patients. Although the rising evidences about its possible role in the treatment of many neurological and psychiatric conditions exist, no evidences exist abou...

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Despite advances in resting state functional magnetic resonance imaging investigations, clinicians remain with the challenge of how to implement this paradigm on an individualized basis. Here, we assessed the clinical relevance of resting state functional magnetic resonance imaging acquisitions in patients with disorders of consciousness by means of a systems-level approach. Three clinical cent...

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Clinical Response to tDCS Depends on Residual Brain Metabolism and Grey Matter Integrity in Patients With Minimally Conscious State.

BACKGROUND Transcranial direct current stimulation (tDCS) was recently shown to promote recovery of voluntary signs of consciousness in some patients in minimally conscious state (MCS). However, it remains unclear why clinical improvement is only observed in a subgroup of patients. OBJECTIVES In this retrospective study, we investigated the relationship between tDCS responsiveness and neuroim...

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Reply: Response to 'Minimally conscious state or cortically mediated state?'

Sir, In a recent review ‘Minimally conscious state or cortically mediated state?’ Naccache argues that the minimally conscious state (MCS) should be relabelled the ‘cortically mediated state (CMS)’ (Naccache, 2017). Naccache motivates this change of nomenclature by arguing that the criteria associated with the MCS ‘do not inform us about the potential residual consciousness of patients, but the...

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Functional Evaluation of Awareness in Vegetative and Minimally Conscious State

OBJECTIVE The aim of this study was to assess differences in brain activation in a large sample of Vegetative State (VS) and Minimally Conscious State (MCS) patients, using functional magnetic resonance imaging (fMRI). METHODS We studied 50 patients four to seven months after brain injury. By using international clinical criteria and validated behavioural scales such as the Glasgow Coma Scale...

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ژورنال

عنوان ژورنال: Frontiers in Cellular Neuroscience

سال: 2016

ISSN: 1662-5102

DOI: 10.3389/fncel.2016.00257